Cutaneous Clopidogrel Hypersensitivity
نویسندگان
چکیده
منابع مشابه
Immediate hypersensitivity and delayed hypersensitivity to clopidogrel.
Clopidogrel is a new antiplatelet prescribed for the secondary prevention of atherosclerotic events. The literature shows that the clinical manifestations of clopidogrel hypersensitivity include urticaria1, skin rash2-4, and angioedema5. The precise immunological mechanism underlying clopidogrel hypersensitivity has not been established. We describe two cases of hypersensitivity reaction due to...
متن کاملCutaneous Basophil Hypersensitivity
Delayed onset erythematous skin reactions elicited in guinea pigs early in the course of sensitization with azobenzenearsonate-protein conjugates or with protein antigens in incomplete Freund's adjuvant or in saline were found to have a characteristic morphology which sets them apart from delayed hypersensitivity and the classic antibody mediated reactions. The principle feature was massive der...
متن کاملCharacterization of clopidogrel hypersensitivity reactions and management with oral steroids without clopidogrel discontinuation.
OBJECTIVES The purpose of this study was to characterize clopidogrel hypersensitivity and describe its successful management with oral steroids without clopidogrel discontinuation. BACKGROUND Hypersensitivity reactions to clopidogrel are poorly understood and present difficulty in management. METHODS Patients diagnosed with clopidogrel hypersensitivity after percutaneous coronary interventi...
متن کاملUse of prasugrel in a patient with clopidogrel hypersensitivity.
OBJECTIVE To report a case of successful use of prasugrel following percutaneous coronary intervention with placement of a bare metal stent in a patient with a documented hypersensitivity reaction to clopidogrel. CASE SUMMARY A 61-year-old male with a history of coronary artery disease with coronary stent placement presented with ST-elevation myocardial infarction. The patient had developed S...
متن کاملGenetic control of cutaneous basophil hypersensitivity
CBH to DNP-GL could be elicited only in responder guinea pigs which possess the genetic ability to develop classic delayed type hypersensitivity to DNP-PLL, the response to which is governed by the same gene. Since the defect in nonresponder animals seems to reside at the level of their T cells and not B cells, these results lend support to the contention that CBH, as well as DH, is dependent o...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2011
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2011.06.036